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April 26, 2026ACS Omega0 citationsOpen Access

Regioselective Iridium-Catalyzed C(7)–H Borylation of Free N –H 6-Fluoroquinolones

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ECEimear CourtneyJMJames MulcahyAHAobha Hickey

Key Points

  • The aim is to develop a method for regioselective C–H borylation of unprotected 6-fluoroquinolones.
  • Utilized iridium as a catalyst for C–H borylation.
  • Focused on unprotected NH 6-fluoroquinolones.
  • Characterized regioselective outcomes at the 7-position.
  • Achieved good yields of borylated products.
  • Enabled efficient functionalization at the 7-position of 6-fluoroquinolones.

Abstract

Quinolones are widely used as antibiotics, with 6-fluoroquinolones representing a particularly prominent class. In this work, we present an iridium-catalyzed C–H borylation strategy for unprotected NH 6-fluoroquinolones, achieving good yields and enabling efficient functionalization at the critical 7-position.

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Cite This Study

Courtney et al. (2026) studied this question.

synapsesocial.com/papers/69edab424a46254e215b359ahttps://doi.org/10.1021/acsomega.5c11604
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