Randomized trial examines how untreated psychosis duration affects brain connectivity and treatment outcomes in first-episode patients, suggesting underlying neurological links.
Key Points
This study aims to explore the impact of the duration of untreated psychosis on functional connectivity and treatment response in antipsychotic-naïve patients.
One hundred antipsychotic-naïve first-episode psychosis patients underwent resting state fMRI.
Functional connectivity was assessed in the default mode, salience, and central executive networks.
Mediation analyses tested the relationship between duration of untreated psychosis and treatment response through functional connectivity.
Longer duration of untreated psychosis was linked to reduced functional connectivity in default mode, salience, and central executive networks.
Functional connectivity of the central executive and salience networks significantly mediated the relationship between duration of untreated psychosis and treatment response.