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April 26, 2026JCEM Case ReportsOpen Access

Multifocal papillary thyroid carcinoma with RET p.V804M , EML4-ALK fusion, and BRAF V600E positivity

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Authors

JBJacob BeirigerLELeonard E. EstephanLZLubna Zuberi

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Overview

Case report reveals oncogenic heterogeneity in multifocal papillary thyroid carcinoma, suggesting molecular profiling benefits.

Key Points

  • The aim is to highlight the presence of multiple oncogenic drivers in multifocal papillary thyroid carcinoma.
  • Described a 31-year-old female case with multifocal papillary thyroid carcinoma.
  • Identified oncogenic alterations including RET p.V804M mutation, EML4-ALK fusion, and BRAF V600E mutation.
  • Conducted fine needle aspiration and subsequent thyroid lobectomy with lymph node dissection.
  • Histopathology confirmed multifocal papillary thyroid carcinoma with three distinct oncogenic alterations.
  • No lymph node metastasis was found in 23 lymph nodes analyzed.
  • The presence of distinct oncogenic alterations supports the need for comprehensive molecular profiling.

Cite This Study

Beiriger et al. (2026) studied this question.

synapsesocial.com/papers/69edabb84a46254e215b39e5https://doi.org/10.1210/jcemcr/luag072
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Also Consider

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