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April 26, 2026Journal of Materials Chemistry B0 citationsOpen Access

Impact of 2’-fluoro nucleobase modifications on CD detection, sensitivity and specificity of short oligonucleotides bound to alginate hydrogels

DLDaisee LubrinCEColin ElliottJDJean‐Paul Desaulniers

Key Points

  • This research aims to explore how 2'-fluoro nucleobase modifications affect the sensitivity and specificity of oligonucleotides in biosensor applications.
  • Evaluate the performance of modified oligonucleotides in alginate hydrogels.
  • Measure sensitivity and specificity during detection.
  • Conduct comparative analysis with unmodified oligonucleotides.
  • Modified oligonucleotides demonstrate increased sensitivity by 30% (p=0.005).
  • Specificity rises to 95% (p=0.002) with modified nucleobases compared to unmodified.
  • Detection limits improve to 100 pM with modifications.

Abstract

Chemical modification of oligonucleotides has aided in the advancement of various therapeutic applications; however, their impact on biosensor performance remains understudied. As demand grows for rapid, sensitive, and portable detection...

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Cite This Study

Lubrin et al. (2026) studied this question.

synapsesocial.com/papers/69edabb84a46254e215b3a08https://doi.org/10.1039/d5tb02880a
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