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April 26, 2026Diabetologia0 citationsOpen Access

Bmal1 overexpression in suprachiasmatic nucleus protects from retinal neurovascular deficits in a mouse model of diabetes

NMNeha MahajanQLQianyi LuoJLJodi Lukkes

Key Points

  • The study aims to explore how overexpressing the clock gene Bmal1 can alleviate neurovascular and metabolic issues caused by type 2 diabetes.
  • Central overexpression of Bmal1 in mice
  • Assessment of metabolic and neurovascular deficits related to diabetes
  • Evaluation of circadian rhythm integration in diabetes management
  • Bmal1 overexpression significantly reduces retinal neurovascular deficits in diabetic mice.
  • Metabolic improvements were observed following Bmal1 central overexpression, indicating a potential protective effect.

Abstract

Our study highlights the therapeutic potential of central overexpression of a clock gene, Bmal1, to mitigate metabolic and neurovascular deficits of type 2 diabetes, offering a compelling framework for incorporating circadian rhythms into managing diabetes and its complications.

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Cite This Study

Mahajan et al. (2026) studied this question.

synapsesocial.com/papers/69edabdf4a46254e215b3c4chttps://doi.org/10.1007/s00125-026-06734-1
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