The lateral lithiation of pyrazoles: direct, transition-metal-free access to pyrazolopyridinones and pyrazolopyranones

Key Points

• This research aims to explore a novel method for synthesizing pyrazolopyridinones and pyrazolopyranones.
• Utilized lateral lithiation of amidopyrazoles for synthesis.
• Employed nitriles and esters as reactants for producing pyrazolopyridinones and pyrazolopyranones, respectively.
• Ensured the process is transition metal-free for simplified reactions.
• Successfully synthesized pyrazolopyridinones and pyrazolopyranones using the transition metal-free approach.
• Achieved efficient modular synthesis, enhancing the speed and flexibility of chemical processes.