Serum Zinc-α2-glycoprotein levels were significantly lower in obese adolescents compared to healthy controls (2.86 vs 5.10 mg/L; p < 0.001), with a proposed diagnostic cut-off of 3.62 mg/L.
Case-Control (n=77)
Can serum ZAG levels be used as a biomarker to identify obesity in children and adolescents?
Serum ZAG levels are significantly reduced in children and adolescents with obesity, and a cut-off value of 3.62 mg/L shows strong discriminatory ability for identifying obesity.
Tasa de eventos absoluta: 2.86% vs 5.1%
valor p: p=< 0.001
Zinc-α2-glycoprotein (ZAG) is a novel adipokine with a plethora of functions meaningful for the regulation of adipose tissue and insulin sensitivity. Despite research, the role of ZAG in the course of childhood obesity is not fully understood. The aim of this study is to investigate whether the levels of ZAG can be used as a predictive or monitoring biomarker of adolescent obesity. Secondly, to determine the cut-off value of ZAG in blood serum in adolescents with obesity. The study included a group of 77 adolescent patients, including 59 obese patients, and 18 without obesity as healthy control subjects. All study participants had their biochemical parameters assessed by a certified medical laboratory. The recommendations of the Polish Society of Hypertensions were used to assess the blood pressure measurements in each group. ELISA enzyme immunoassays (R p < 0.001). The multivariable Firth’s logistic regression model, incorporating the selected factors, revealed a significant association between obesity and ZAG. ROC curve analysis indicated strong discriminatory ability of ZAG for identifying obesity, with a proposed cut-off value of 3.62 mg/L. Circulating ZAG level is significantly reduced in children and adolescents with obesity. An important finding of our study is the detection of a cutoff value for serum ZAG levels. Furthermore, the use of the Least Absolute Shrinkage and Selection Operator (LASSO) model can be considered a valuable contribution to defining ZAG as an independent factor associated with obesity.
Siewert et al. (Thu,) conducted a case-control in Obesity (n=77). Serum Zinc-α2-glycoprotein (ZAG) measurement vs. Healthy control subjects without obesity was evaluated on Serum ZAG concentration (p=< 0.001). Serum Zinc-α2-glycoprotein levels were significantly lower in obese adolescents compared to healthy controls (2.86 vs 5.10 mg/L; p < 0.001), with a proposed diagnostic cut-off of 3.62 mg/L.