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April 26, 2026European Journal of Neurology0 citationsOpen Access

The Relevance of Crystal Clear and Unclear Days to Evaluate Residual Interictal Burden in Patients With Migraine Treated With CGRP Monoclonal Antibodies

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MSMarcello SilvestroIOIlaria OrologioRORaffaele Ornello

Key Points

  • This research aims to evaluate the residual interictal burden in migraine patients beyond attack control by focusing on crystal clear and unclear days.
  • Examined the relationship between crystal clear and unclear days and interictal burden in migraine patients.
  • Considered the impact of CGRP monoclonal antibody treatment on these days.
  • Unclear days are closely associated with residual interictal burden despite effective migraine treatment.
  • Crystal clear days provide a positive indication of interictal recovery in patients.

Abstract

Even when migraine attacks are adequately controlled, residual interictal burden may remain and seems to be predominantly associated with unclear days rather than with residual attacks. Assessing crystal clear and unclear days provides a complementary, patient-centered perspective on treatment response and interictal recovery in migraine.

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Cite This Study

Silvestro et al. (2026) studied this question.

synapsesocial.com/papers/69edacbd4a46254e215b4733https://doi.org/10.1111/ene.70608
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