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April 26, 2026Human Vaccines & ImmunotherapeuticsOpen Access

Pre-vaccination immune signatures of children with inborn errors of immunity associate with COVID-19 vaccine response

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Authors

PPPaolo PalmaEEElena EmiliCPChiara Pighi

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Overview

Randomized trial identifies immune markers predicting vaccine response in children with inborn errors of immunity, suggesting personalized strategies.

Key Points

  • This study aims to uncover baseline immune transcriptional signatures related to vaccine responses in children with inborn errors of immunity.
  • Twenty-one SARS-CoV-2-naïve participants with inborn errors of immunity were studied.
  • Participants were categorized as high or low responders based on IgG titers at day 28 post-vaccination.
  • Transcriptional profiling was performed to identify differentially expressed genes at baseline.
  • Low responders demonstrated significantly lower frequencies of switched memory B cells (p = .014).
  • 41 genes were identified as differentially expressed between high and low responders at baseline.
  • High responders exhibited greater induction of activation-related genes, indicating readiness for antibody production.

Cite This Study

Palma et al. (2026) studied this question.

synapsesocial.com/papers/69edacdb4a46254e215b4885https://doi.org/10.1080/21645515.2026.2661495
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