The risk of sudden cardiac death in childhood cardiomyopathy varied by phenotype (P=0.007), with a 15-year cumulative incidence of 5% for DCM, 6% for HCM, 12% for RCM, and 23% for LV noncompaction.
Cohort
Yes
What is the incidence and what are the risk factors for sudden cardiac death in children with primary cardiomyopathy?
289 children in Australia with primary cardiomyopathy diagnosed between January 1, 1987, and December 31, 1996, who were <10 years of age
Incidence and risk factors for sudden cardiac death (SCD)hard clinical
In children with primary cardiomyopathy, the risk of sudden cardiac death varies significantly by phenotype, with left ventricular noncompaction having the highest 15-year cumulative incidence.
BACKGROUND: Children with cardiomyopathy (CM) are at risk of sudden cardiac death (SCD), but the incidence and risk factors for this outcome are not clear. OBJECTIVES: This study sought to determine the incidence and risk factors for SCD in children with varying CM phenotypes from a long-term population-based study of childhood CM. METHODS: The NACCS (National Australian Childhood Cardiomyopathy Study) is an ongoing longitudinal cohort study including all children in Australia with primary CM who were diagnosed between January 1, 1987, and December 31, 1996, and were <10 years of age. The cumulative incidence and risk factors for SCD within individual CM phenotypes were explored using survival analysis. RESULTS: Of 289 eligible patients, 16 (5.5%) experienced SCD over a median follow-up of 11.9 years (interquartile range: 1.7 to 15.4). The risk of SCD varied according to CM phenotype (p=0.007). The cumulative incidence of SCD at 15 years was 5% for dilated cardiomyopathy (DCM), 6% for hypertrophic cardiomyopathy (HCM), 12% for restrictive cardiomyopathy, and 23% for left ventricular (LV) noncompaction. Older age at diagnosis, positive family history of CM, and severity of LV dysfunction were related to increased risk of SCD in patients with DCM, and a higher posterior wall thickness Z-score was the sole risk factor identified for patients with HCM. CONCLUSIONS: Predictors of SCD include CM phenotype, family history of CM (DCM), severity of systolic dysfunction (DCM), and extent of LV hypertrophy (HCM). Continuing follow-up of this cohort into adulthood is likely to reveal an ongoing risk of SCD.
Building similarity graph...
Analyzing shared references across papers
Loading...
Bharucha et al. (Mon,) conducted a cohort in Childhood Cardiomyopathy (n=289). Observation was evaluated on Sudden cardiac death (SCD) (p=0.007). The risk of sudden cardiac death in childhood cardiomyopathy varied by phenotype (P=0.007), with a 15-year cumulative incidence of 5% for DCM, 6% for HCM, 12% for RCM, and 23% for LV noncompaction.
www.synapsesocial.com/papers/69ee2ce19de2ebe493710044 — DOI: https://doi.org/10.1016/j.jacc.2015.03.552
Tara Bharucha
Katherine J. Lee
Piers E.F. Daubeney
Journal of the American College of Cardiology
Harvard University
The University of Melbourne
The University of Texas Southwestern Medical Center
Building similarity graph...
Analyzing shared references across papers
Loading...