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April 27, 2026Neurology2 citationsOpen Access

Association of MRI-Visible Perivascular Spaces With Longitudinal Cognitive Decline Over a Decade

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KKKyoko KohnoYSYunyi SunJLJames D. LeFevre

Key Points

  • To investigate the independent association of basal ganglia perivascular spaces with cognitive decline over a decade.
  • Assess longitudinal changes in cognitive function over ten years
  • Measure perivascular spaces using MRI
  • Evaluate executive function and visuospatial skills independent of other markers
  • Increased perivascular spaces correlate with worse executive function scores over time (p<0.05)
  • Visuospatial skills decline significantly with higher PVS burden (p<0.05)
  • Findings suggest that PVS likely contributes to cognitive deterioration independent of small vessel disease markers.

Abstract

Basal ganglia PVS burden independently contributes to worse longitudinal executive function and visuospatial skills independent of other SVD markers, highlighting PVS as an emerging marker of domain-specific cognitive decline in aging. Although causation cannot be established, findings further support PVS as a vascular contributor to deep brain structure damage underlying cognitive decline over time.

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Cite This Study

Kohno et al. (2026) studied this question.

synapsesocial.com/papers/69eefc23fede9185760d34a2https://doi.org/10.1212/wnl.0000000000214803
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