Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 27, 2026SHILAP Revista de lepidopterologíaOpen Access

Transcriptomic analysis and experimental verification reveal the involvement of PI3K/AKT signaling pathway in high-altitude cognitive dysfunction

View Full Paper
Ask AI
Bookmark
Share

Authors

YXYu XinCYChenyu YangGWGege Wang

Discussion

Loading...

Member takes

Overview

Randomized trial investigates gene pathways linked to cognitive dysfunction in mice, suggesting novel treatment avenues.

Key Points

  • This study aimed to characterize molecular mechanisms behind high-altitude cognitive dysfunction in mice.
  • Mice were divided into control and hypobaric hypoxia groups.
  • Cognitive function was assessed using novel object recognition and Morris water maze tests.
  • RNA-Seq was used to analyze gene expression and identify differentially expressed genes.
  • Exposure to hypobaric hypoxia led to significant cognitive impairment and changes in hippocampal tissue.
  • A total of 178 differentially expressed genes were identified, along with 8 hub genes associated with the PI3K/AKT pathway.
  • PI3K/AKT pathway inhibition was confirmed with decreased antioxidant protein levels and increased neuroinflammation.

Cite This Study

Xin et al. (2026) studied this question.

synapsesocial.com/papers/69eefc23fede9185760d34e4https://doi.org/10.3389/fphys.2026.1781613
View Full Paper
Ask AI
Bookmark
Share