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April 27, 2026Artificial Cells Nanomedicine and BiotechnologyOpen Access

MMP9 as a shared immune-related gene in Alzheimer’s and Huntington’s diseases: a cross-tissue transcriptomic analysis

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Authors

XLXuepan LiCZC L ZhangHNHaisen Ni

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Overview

Cross-tissue transcriptomic analysis identifies MMP9 as a shared neuroinflammatory marker in Alzheimer’s and Huntington’s diseases, suggesting its potential as a therapeutic target.

Key Points

  • This research aims to uncover shared immune-related mechanisms in Alzheimer's and Huntington's diseases through transcriptomic analysis.
  • Integrated transcriptomic profiles of peripheral blood and frontal cortex tissues with 2,160 immune-related genes.
  • Conducted differential analysis to identify dysregulated immune genes, pinpointing key co-expressed genes.
  • Applied machine learning techniques (LASSO and Boruta) to validate MMP9 as a core immune hub gene.
  • Identified 10 co-expressed all-immune genes shared between Alzheimer's and Huntington's diseases.
  • MMP9 demonstrated modest diagnostic performance in peripheral blood (AD AUC = 0.616; HD AUC = 0.619) and stronger accuracy in brain tissues (AD AUC = 0.825; HD AUC = 0.876).
  • MMP9 expression positively correlated with neutrophil and M0 macrophage infiltration, indicating its role in neuroinflammation.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69eefc6dfede9185760d3711https://doi.org/10.1080/21691401.2026.2644164
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative Multi-Omics Analysis Identifies Shared Transcriptomic Signatures and Therapeutic Targets in Alzheimer’s, Parkinson’s, and Huntington’s Diseases2025
  2. 2Comparative Multi-Omics Analysis Identifies Shared Transcriptomic Signatures and Therapeutic Targets in Alzheimer’s, Parkinson’s, and Huntington’s Diseases2025 · 4 citations
  3. 3Matrix Remodeling Enzymes as Potential Fluid Biomarkers of Neurodegeneration in Alzheimer’s Disease2024 · 11 citations
  4. 4MMP9 Serves as a Prognostic Biomarker and Immune‐Associated Regulator in Diffuse Large B‐Cell Lymphoma2026
  5. 5Immune system-associated genes in patients with Alzheimer's disease2025