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April 27, 2026Journal of Drug Delivery Science and TechnologyOpen Access

Nanoemulsion-Based Strategy for Azithromycin Administration in Paediatrics

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Authors

AIAnna ImbrianoUniversity of PerugiaAMAlessandro Di MicheleUniversity of PerugiaMCMaria Rachele CeccariniUniversity of Perugia

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Overview

Randomized trial evaluates nanoemulsion's effectiveness in improving azithromycin delivery for pediatric use, suggesting better taste and stability.

Key Points

  • This research aims to optimize a nanoemulsion formulation for azithromycin delivery, addressing its solubility and taste issues in pediatric patients.
  • High-Power Ultrasonic technique used for producing the oil-in-water nanoemulsion with pumpkin seed oil.
  • D-optimal experimental design optimized droplet size, polydispersity index, and zeta potential of the formulation.
  • Antimicrobial activity assessed through agar diffusion and time-kill tests against Gram-positive bacteria.
  • Optimized nanoemulsion achieved a droplet size of approximately 800 nm, PDI <0.08, and zeta potential around -20 mV.
  • Demonstrated antimicrobial activity at 23 μg/mL compared to 400 μg/mL for commercial azithromycin suspension.
  • Reduced azithromycin binding to the TAS2R4 receptor, indicating potential for improved administration.

Cite This Study

Imbriano et al. (2026) studied this question.

synapsesocial.com/papers/69eefc6dfede9185760d3859https://doi.org/10.1016/j.jddst.2026.108368
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