Climbing mountain with MacTrigger: DDS technologies to treat cancer

Key Points

• The aim is to develop a novel treatment method utilizing genetically modified macrophages to combat cancer.
• Developed gene-modified macrophages named MacTrigger that release TNF-α upon accumulating in cancer tissue.
• Administered MacTrigger intravenously to induce strong acute inflammation in tumors.
• Analyzed the shift of tumors into inflammatory environments, enhancing immune response against cancer.
• MacTrigger successfully transformed tumor environments into inflammatory tissues, facilitating immune attack against cancer.
• Efficacy marked by induction of TNF-α release led to enhanced activation of NK cells and cytotoxic T cells against tumor cells.

Abstract