Ganglioneuroma with mesenteric involvement: An atypical presentation of a rare neoplasm

Ganglioneuromas are benign neoplasms of the neuroblastic tumor family, primarily arising from neural crest cells within the sympathetic nervous system. They are often asymptomatic and detected incidentally upon imaging for different conditions, commonly found in the mediastinum, retroperitoneum, and adrenal glands. This case report described the diagnosis and management of a 40-year-old female with a retroperitoneal ganglioneuroma featuring mesenteric involvement. The nonspecific imaging features and clinical presentation necessitated histological examination, which ultimately confirmed the diagnosis of a ganglioneuroma of mesenteric origin. The patient underwent complete surgical resection with an uneventful recovery and remains free of recurrence 15 years post-treatment. This case underscores the importance of integrating clinical, radiological, and histological findings to differentiate GNs from other soft tissue abdominal masses.