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April 27, 2026Scientific ReportsOpen Access

SIRT1-mediated deacetylation of HMGB1 promotes the progression of endometriosis by regulating autophagy

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Authors

YLYi LanLWLan WangZHZhen Huang

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Overview

Randomized trial uncovers the role of SIRT1 in regulating autophagy and promoting endometriosis, highlighting new treatment avenues.

Key Points

  • This research investigates the role of SIRT1-mediated deacetylation of HMGB1 in the progression of endometriosis.
  • Collected normal, ectopic, and eutopic endometrial tissues from EMs or non-EMs patients.
  • Assessed cell viability, migration, and invasion using MTT and Transwell assays.
  • Developed an EMs rat model to study SIRT1 silencing effects on HESCs.
  • Elevated SIRT1 expression was observed in both eutopic and ectopic endometrial tissues.
  • SIRT1 deficiency led to significant reductions in HESC viability (p<0.01), migration (p<0.01), and invasion (p<0.01), alongside diminished autophagy.
  • HMGB1 overexpression increased HESC viability, migration, invasion, and enhanced autophagy, inducing a notable phenotypic shift.

Cite This Study

Lan et al. (2026) studied this question.

synapsesocial.com/papers/69eefd15fede9185760d3cc9https://doi.org/10.1038/s41598-026-44527-z
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