Combination of Xingnaojing injection and acupuncture ameliorate traumatic brain injury by promoting M2 polarization of microglia through KAT2A-mediated HMGB1 succinylation

Key Points

• The aim is to evaluate the effectiveness of combined Xingnaojing injection and acupuncture for enhancing recovery in traumatic brain injury by targeting microglial polarization.
• Combination therapy of Xingnaojing injection and acupuncture was implemented in TBI patients.
• Effects on M2 microglial polarization and HMGB1 succinylation via KAT2A were assessed.
• Combination therapy significantly promoted M2 polarization of microglia.
• Improvement in recovery metrics was observed, indicating enhanced therapeutic potential.

Abstract