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April 27, 2026Clinical Chemistry and Laboratory Medicine (CCLM)0 citations

Performance evaluation of five large language models for assisting in the interpretation of urinalysis reports for kidney diseases: a real-world study

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TLTao LiuXQXinglun QiMGMohui Guo

Key Points

  • This study aims to evaluate the effectiveness of large language models in interpreting urinalysis reports for diagnosing kidney diseases.
  • Evaluated five large language models in urinalysis interpretation using real-world data.
  • Focused on instrument-specific flag interpretation and hallucination mitigation.
  • Explored Retrieval-Augmented Generation integration and human oversight for improved accuracy.
  • Proprietary models showed superior reasoning capabilities compared to others.
  • Significant challenges in flag interpretation and hallucination resistance were identified, indicating areas for improvement.
  • Human oversight is recommended to enhance model performance during interpretation.

Abstract

LLMs demonstrate significant capability in urinalysis interpretation, though proprietary models currently excel in reasoning and hallucination resistance. Instrument-specific flag interpretation and hallucination mitigation remain critical challenges requiring Retrieval-Augmented Generation (RAG) integration and human oversight.

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Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69eefdb5fede9185760d47b6https://doi.org/10.1515/cclm-2026-0435
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