What question did this study set out to answer?

To develop a method for synthesizing 8-membered tetrahydroazocines using manganese-mediated processes.

April 29, 2026Organic Chemistry Frontiers0 citations

Synthesis of 8-membered Tetrahydroazocines via Manganese-Mediated Regioselective Sulfonylation/Cyclization of N-Substituted Enamides with Sodium Sulfinites

RDRan Ding CZChuan-Hao Zhang JYJia-Qi Yuan

Key Points

To develop a method for synthesizing 8-membered tetrahydroazocines using manganese-mediated processes.
Utilized manganese-mediated sulfonylation and cyclization techniques.
Investigated regioselective reactions involving N-substituted enamides and sodium sulfinites.
Applied radical cascade cyclization with tethered alkynes.
Successfully synthesized 8-membered tetrahydroazocines through the described method.
Demonstrated effectiveness in creating benzene-fused heterocyclic compounds.

Abstract

Intermolecular radical cascade cyclization of tethered alkynes involving the cracking of aryl or vinyl C(sp2)–H has become an important pathway for the synthesis of benzene-fused or C=C bond-containing heterocyclic building...

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Cite This Study

Ding et al. (2026) studied this question.

synapsesocial.com/papers/69f154a4879cb923c4944e13 https://doi.org/10.1039/d6qo00401f

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April 29, 2026Organic Chemistry Frontiers0 citations

Synthesis of 8-membered Tetrahydroazocines via Manganese-Mediated Regioselective Sulfonylation/Cyclization of N-Substituted Enamides with Sodium Sulfinites

View Full Paper

RDRan Ding CZChuan-Hao Zhang JYJia-Qi Yuan

Key Points

To develop a method for synthesizing 8-membered tetrahydroazocines using manganese-mediated processes.
Utilized manganese-mediated sulfonylation and cyclization techniques.
Investigated regioselective reactions involving N-substituted enamides and sodium sulfinites.
Applied radical cascade cyclization with tethered alkynes.
Successfully synthesized 8-membered tetrahydroazocines through the described method.
Demonstrated effectiveness in creating benzene-fused heterocyclic compounds.

Abstract

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Cite This Study

Ding et al. (2026) studied this question.

synapsesocial.com/papers/69f154a4879cb923c4944e13 https://doi.org/10.1039/d6qo00401f

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