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April 29, 2026Lipids in Health and DiseaseOpen Access

TyHGB as a predictive marker for preeclampsia: association with increased risk in pregnant women with normal glucose tolerance

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Authors

YBYongying BaiYXYa XiJHJiamin Huang

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Overview

Randomized trial tests the link between TyHGB and preeclampsia risk in pregnant women, indicating it could enhance screening.

Key Points

  • This study aimed to investigate the association between TyHGB levels and the risk of developing preeclampsia in pregnant women.
  • Enrolled 23,219 singleton pregnant women and stratified into TyHGB quartiles.
  • Utilized multivariable regression and subgroup analyses to assess TyHGB's association with preeclampsia.
  • Evaluated model performance using ROC curves, calibration curves, and decision curve analysis.
  • Each 1-unit increase in TyHGB corresponds to a 1.61-fold increase in preeclampsia risk (P < 0.001).
  • The highest TyHGB quartile showed a relative risk of 3.27 (95% CI: 2.15–4.97) compared to the lowest quartile.
  • The predictive model achieved an AUC of 0.682 with a sensitivity of 73.85% and specificity of 53.82%.

Cite This Study

Bai et al. (2026) studied this question.

synapsesocial.com/papers/69f19f9cedf4b4682480661fhttps://doi.org/10.1186/s12944-026-02962-x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association between TyHGB and gestational diabetes mellitus: a large-scale retrospective cross-sectional study2026
  2. 2Triglyceride-glucose index: A promising biomarker for predicting risks of adverse pregnancy outcomes in Hangzhou, China2024 · 11 citations
  3. 3Associations between triglyceride-glucose index in the early trimester of pregnancy and adverse pregnancy outcomes2025 · 2 citations
  4. 4Triglyceride-glucose index in early pregnancy predicts the risk of gestational diabetes: a prospective cohort study2024 · 42 citations
  5. 5Association between triglyceride glucose-body mass index and preeclampsia risk in advanced maternal age pregnant women-a retrospective cohort study2025