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April 29, 2026Case Reports in GastroenterologyOpen Access

Successful Treatment of Refractory Pruritus in Primary Sclerosing Cholangitis with Upadacitinib: A Case Report

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Authors

HNHuzaifa NadeemPLPeter L. LakatosHHHamila Hagh-Doust

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Overview

Case report reveals upadacitinib effectively resolves pruritus in primary sclerosing cholangitis, suggesting new treatment avenues.

Key Points

  • This report aims to demonstrate the effect of upadacitinib on refractory pruritus in a patient with primary sclerosing cholangitis.
  • Case report of a 32-year-old male with PSC and Crohn's disease who experienced refractory pruritus.
  • Initiation of upadacitinib for Crohn's disease flare, monitoring the resolution of pruritus.
  • Evaluation of patient’s quality of life and liver transplant necessity before and after treatment.
  • Pruritus resolved completely within 48–72 hours after initiating upadacitinib.
  • Maintenance therapy sustained symptom relief for over 27 months.
  • Patient remained symptom-free and inactive on the liver transplant waitlist due to improved quality of life.

Cite This Study

Nadeem et al. (2026) studied this question.

synapsesocial.com/papers/69f19fd5edf4b4682480690dhttps://doi.org/10.1159/000552074
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pruritus is common in primary sclerosing cholangitis, persists over time, and its intensity is associated with disease severity: a multicentre, prospective observational study2025
  2. 2Pruritus is common in primary sclerosing cholangitis, persists over time, and its intensity is associated with disease severity2025 · 6 citations
  3. 3A multinational survey assessing the impact and burden of pruritus on patients with primary sclerosing cholangitis2026 · 1 citations
  4. 4Pruritus Is Frequent and Persistent and Impacts Quality of Life Among Patients With Primary Sclerosing Cholangitis2026
  5. 5Safety and Efficacy of Upadacitinib in Patients with Inflammatory Bowel Disease After Liver Transplantation: A Case Series2025