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April 30, 2026Open Access

2D and 3D Cancer Models Reveal Upregulated ANGPTL4 Secretion in p53C176F/Y Mutant Cells

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Authors

PSPolina Shevchuk

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Overview

Analysis reveals that TP53 mutations enhance ANGPTL4 secretion in prostate and lung cancer cells, indicating potential therapeutic strategies.

Key Points

  • This research aims to understand how TP53 mutations influence tumour biology, specifically focusing on ANGPTL4 secretion.
  • Utilized 2D and 3D cancer models to study p53C176F/Y mutant cells
  • Analyzed gene targets using RNA-sequencing
  • Conducted immunofluorescent staining to assess protein levels
  • Performed siRNA knockdown experiments to evaluate regulatory mechanisms
  • Identified upregulated ANGPTL4 secretion in prostate and lung cancer cells with p53C176F/Y mutations
  • Demonstrated that p53C176F/Y mutants alter ANGPTL4 secretion independently of direct transcriptional regulation
  • Observed divergence in biological effects between p53C176F and p53C176Y mutations

Cite This Study

Polina Shevchuk (2026) studied this question.

synapsesocial.com/papers/69f2a42a8c0f03fd67763348https://doi.org/10.82348/our-archive.00114
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