April 30, 2026Organic & Biomolecular Chemistry0 citations

Synthesis of Cyanodifluoromethylselenylated Isocoumarins Enabled by a p-CF3BnSe(O)CF₂CN/Tf2O Reagent System

JWJialiang Wu MTMeiling Tian JHJiaxin He

Resumen

p-CF3BnSe(O)CF2CN was developed as a cyanodifluoromethylselenonating reagent. In combination with Tf2O, this reagent system enabled an efficient synthesis of the biologically interesting 4-(cyanodifluoromethylseleno) isocoumarins from 2-alkynylbenzoates. Mechanistically, the transformation was...

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Wu et al. (Wed,) studied this question.

synapsesocial.com/papers/69f2a4578c0f03fd67763539 https://doi.org/https://doi.org/10.1039/d6ob00469e

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