To enhance the affinity of CEMP1 N-terminal 20-residue peptide for collagen through glycine-proline-hydroxyproline modification.
Glycine-proline-hydroxyproline modification applied to CEMP1 n-terminal peptide.
Affinity measurements for collagen compared before and after modification.
Glycine-proline-hydroxyproline modification significantly increased the affinity of the peptide for collagen.
Improved binding may enhance the application of CEMP1 in tissue engineering.
Abstract
N-terminal 20 peptide of cementum matrix protein 1 (CEMP1) shows the affinity for hydroxyapatite (HAP) and induces the nucleation of HAP. However, its poor affinity for collagen limits its application...