Synthesis of Azole-Linked s-Triazine-Isatin Molecular Architectures as Nanoscale DNA-Targeting Agents: A Combined Spectroscopic and Computational Study

Key Points

• This research focuses on developing nanoscale DNA-targeting agents using azole-linked isatin and triazine architectures.
• Synthesis of azole-linked s-triazine-isatin molecular architectures
• Utilization of spectroscopic techniques to analyze the compounds
• Computational studies to evaluate interactions with DNA
• Identified promising DNA-targeting agents with potential anticancer properties
• Showed enhanced interaction with DNA as a biopolymer
• Demonstrated effective replication and transcription inhibition

Abstract