What question did this study set out to answer?

To explore the role of small-molecule analogues in sustaining drug supersaturation and inhibiting precipitation.

April 30, 2026Open Access

Precipitation Inhibition by Small-Molecule Analogues To Sustain Drug Supersaturation

Key Points

To explore the role of small-molecule analogues in sustaining drug supersaturation and inhibiting precipitation.
Used H NMR to analyze heteroassociation of ciprofloxacin with its analogues.
Compared the effects of danofloxacin and other analogues on self-association and aggregation.
Investigated structural mimicry for coformulation design.
Danofloxacin showed significant disruption of ciprofloxacin self-association.
Kinetic mechanism supports the delay of prenucleation aggregates formation.
Small-molecule analogues successfully prolonged drug supersaturation.

Abstract

H NMR revealed concentration-dependent aromatic shielding consistent with ciprofloxacin···analogue heteroassociation, with danofloxacin producing the most substantial and most symmetric perturbations. These data sets support a kinetic mechanism in which isostructural analogues disrupt ciprofloxacin self-association, delay the formation of prenucleation aggregates, and prolong supersaturation. The findings establish small-molecule structural mimicry as a viable pathway for stabilizing supersaturation and guiding mechanism-based coformulation design.

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Authors

Parag Roy

Oisín N. Kavanagh

Journals

Molecular Pharmaceutics

Actions

Institutions

Newcastle University

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Precipitation Inhibition by Small-Molecule Analogues To Sustain Drug Supersaturation

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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