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April 30, 2026Molecular PharmaceuticsOpen Access

Unveiling Solvent-Mediated Mechanochemical Cocrystallization Pathways by In Situ CLASSIC NMR Spectroscopy

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Authors

AGAnna M. GołkowskaMNMaciej NowakLFL. Fábián

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Overview

Randomized trial investigates the effects of solvents on mechanochemical synthesis, suggesting advancements in polymorphic control.

Key Points

  • This research aims to explore how different solvents influence mechanochemical cocrystallization pathways.
  • Utilized in situ CLASSIC NMR spectroscopy to analyze cocrystallization processes.
  • Investigated multiple solvents to assess their effects on crystallization.
  • Focused on identifying reaction pathways for polymorphic control.
  • Identified distinct pathways influenced by various solvents.
  • Demonstrated solvent selection significantly alters cocrystallization outcomes.
  • Revealed insights into the molecular mechanisms underlining polymorphic control.

Cite This Study

Gołkowska et al. (2026) studied this question.

synapsesocial.com/papers/69f2f0991e5f7920c6386bc5https://doi.org/10.1021/acs.molpharmaceut.5c01909
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