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April 30, 2026In Silico Research in Biomedicine0 citationsOpen Access

Integrative HPLC Profiling and Network Pharmacology Unravel Antidiabetic Mechanisms of Ageratum...

Integrated HPLC Profiling and Network Pharmacology Reveal PI3K–Akt–Mediated Antidiabetic Mechanisms of Ageratum conyzoides l

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Authors

PKPrashant KumarSTShashi Bhooshan Tiwari

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Overview

Randomized trial reveals antidiabetic effects of Ageratum conyzoides, suggesting its potential in diabetes treatment.

Key Points

  • This research aims to identify the key phytochemical compounds in Ageratum conyzoides and their mechanisms against diabetes mellitus.
  • HPLC analysis of Ageratum conyzoides leaves to identify major compounds.
  • Evaluation of drug-likeness and ADME properties of compounds using SwissADME.
  • Construction of protein–protein interaction networks and pathway enrichment analyses.
  • Three major compounds identified: scutellarin, kaempferol, and umbelliferone.
  • KEGG enrichment analysis demonstrated significant PI3K–Akt signaling pathway involvement (P<0.01).
  • Molecular docking identified scutellarin as the most effective ligand with multi-target potential.

Cite This Study

Kumar et al. (2026) studied this question.

synapsesocial.com/papers/69f2f0991e5f7920c6386ca5https://doi.org/10.1016/j.insi.2026.100350
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