Rational Design and Development of an Acyclic Chelator H 4 pyox for Theranostic Radiometal Labeling under Mild Conditions

Key Points

• The aim is to develop an acyclic chelator, H4pyox, for effective radiometal labeling in radiopharmaceuticals.
• Designed and synthesized acyclic chelator H4pyox.
• Assessed its labeling efficiency under mild conditions.
• Evaluated pharmacokinetic properties for various targeting vectors.
• H4pyox exhibits enhanced radiometal labeling efficiency compared to previous chelators.
• Improved pharmacokinetic properties were noted for radiopharmaceuticals targeting vectors with low thermal stability.