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April 30, 2026BMC Cardiovascular Disorders0 citationsOpen Access

Prevalence and Predictors of Apparent Treatment-Resistant Hypertension in Northeast Ethiopia

Apparent treatment-resistant hypertension in ambulatory hypertensive patients in Northeast Ethiopia: prevalence, treatment patterns, and predictors

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Why the study?

Data on apparent treatment-resistant hypertension in sub-Saharan Africa remain scarce, and the Northeast Amhara region of Ethiopia has been particularly underexplored.

Population

240 ambulatory adult hypertensive patients on at least one antihypertensive medication in Northeast Ethiopia

Design

Multi-center cross-sectional study

Key result

Apparent treatment-resistant hypertension was observed in 9.2% of patients, with at least one-time change in antihypertensive regimens being the sole predictor (AOR 2.85).

Authors

MHMinimize HassenMHMohammed Yimam HassenBYBetelhem Girma Yehualashet

Discussion

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Overview

Hypothesis-generating for regimen changes predicting aTRH; prospective studies needed before clinical adoption.

Key Points

  • This study investigates the prevalence, treatment patterns, and predictors of apparent treatment-resistant hypertension among ambulatory adult hypertensive patients.
  • Multi-center cross-sectional study conducted with 240 hypertensive patients from two hospitals in Northeast Ethiopia.
  • Patients selected via multistage sampling and data collected through medical record reviews.
  • Logistic regression analysis used to identify factors associated with apparent treatment-resistant hypertension.
  • Apparent treatment-resistant hypertension was found in 9.2% of patients.
  • 56.2% had poorly controlled blood pressure at follow-up.
  • At least one change in antihypertensive regimen was associated with aTRH (AOR: 2.85, 95% CI: 1.14–7.10, p = 0.025).

Study Design

Type

Cross-Sectional (n=240)

Multicenter

Yes

Structured PICO

P
Population
240 ambulatory adult hypertensive patients on at least one antihypertensive medication attending hypertension clinics in Dessie Comprehensive Specialized Hospital and Boru Meda General Hospital in Northeast Ethiopia
O
Outcome
Prevalence, treatment pattern, and predictors of apparent treatment-resistant hypertension (aTRH)

Apparent treatment-resistant hypertension is prevalent (9.2%) among ambulatory hypertensive patients in Northeast Ethiopia, with regimen changes being a significant predictor.

Main Result

Effect estimate: AOR 2.85 (95% CI 1.14-7.10)

p-value: p=0.025

Limitations

  • Retrospective cross-sectional design limits causal inference
  • Exclusion of patients due to incomplete medical records and missing consecutive monthly BP readings

Cite This Study

Hassen et al. (2026) conducted a cross-sectional in Hypertension (n=240). Antihypertensive regimen change vs. No regimen change was evaluated on Apparent treatment-resistant hypertension (aTRH) (AOR 2.85, 95% CI 1.14-7.10, p=0.025). Apparent treatment-resistant hypertension was observed in 9.2% of patients, with at least one-time change in antihypertensive regimens being the sole predictor (AOR 2.85).

synapsesocial.com/papers/69f2f0e31e5f7920c6386d83https://doi.org/10.1186/s12872-026-05921-7
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