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April 30, 2026Nucleosides Nucleotides & Nucleic Acids0 citations

d -Alanyl: d -alanine ligase inhibitors as antibacterial agents against Staphylococcus aureus : a review

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MAMohammed Afzal AzamATAbisha ThomasSJSrikanth Jupudi

Key Points

  • This review aims to evaluate the effectiveness of d-alanine ligase inhibitors as potential antibacterial agents against Staphylococcus aureus.
  • Comprehensive literature review of d-alanine ligase inhibitors
  • Analysis of antibacterial properties against gram-positive pathogens
  • Evaluation of resistance mechanisms in Staphylococcus aureus.
  • D-alanine ligase inhibitors demonstrated significant antibacterial activity against Staphylococcus aureus.
  • Evidence suggests these inhibitors could overcome current antibiotic resistance.
  • Potential for development into new therapeutic agents for treating infections.

Abstract

Gram-positive pathogen

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Cite This Study

Azam et al. (2026) studied this question.

synapsesocial.com/papers/69f2f0e31e5f7920c6386e41https://doi.org/10.1080/15257770.2026.2661075
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  5. 5Pharmacomodulations of the benzoyl-thiosemicarbazide scaffold reveal antimicrobial agents targeting d-alanyl-d-alanine ligase in bacterio2020 · 31 citations