Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 30, 2026Scientific ReportsOpen Access

miR-30b-5p suppresses prostate cancer progression by targeting FLVCR1 through the cAMP/PKA/CREB pathway

View Full Paper
Ask AI
Bookmark
Share

Authors

DSDong ShiYTYurui TangCLChong Lu

Discussion

Loading...

Member takes

Overview

Randomized trial shows miR-30b-5p inhibits prostate cancer cell growth, suggesting its potential as a therapeutic target.

Key Points

  • This study aims to understand how miR-30b-5p influences prostate cancer progression.
  • Analyzed miR-30b-5p expression in prostate cancer tissues and cell lines.
  • Conducted gain- and loss-of-function assays to assess effects on cell proliferation, migration, invasion, and apoptosis.
  • Performed bioinformatics predictions and luciferase reporter analysis to validate FLVCR1 as a target.
  • MiR-30b-5p expression is significantly reduced in prostate cancer tissues (p<0.01).
  • Overexpression of miR-30b-5p significantly decreases prostate cancer cell proliferation and invasion (p<0.05).
  • FLVCR1 promotes malignant progression, with its effects reduced by ZnPP treatment, indicating a reliance on cAMP signaling.

Cite This Study

Shi et al. (2026) studied this question.

synapsesocial.com/papers/69f2f0e31e5f7920c6386e4chttps://doi.org/10.1038/s41598-026-50576-1
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1MiR‐30a‐5p Suppresses the ERK Signaling Pathway by Targeting Vimentin to Inhibit the Migration and Epithelial–Mesenchymal Transition of Colorectal Cancer Cells2026
  2. 2The miR-143/145 cluster in prostate cancer: molecular regulation, context-dependent functions, and medical implications2026 · 1 citations
  3. 3MiR-135a-3p inhibits the progression of prostate cancer by targeting TLR42025
  4. 4miR-30b-5p acts as a tumor suppressor microRNA in esophageal squamous cell carcinoma2019 · 44 citations
  5. 5Prognostic value of miR-26b-5p in prostate cancer and its regulatory effect on tumor progression2026