Identification of an Orally Efficacious Imidazo4,5- c pyridine-6-Carboxamide Antimalarial with a High Barrier to Resistance

Key Points

• The research aims to discover a new antimalarial that is effective against resistant strains of parasites.
• Designed an orally efficacious imidazopyridine compound targeting proliferating and dormant parasite stages.
• Assessed the compound's efficacy against dihydroartemisinin-induced dormant parasites.
• The compound effectively killed both proliferating parasites and dihydroartemisinin-induced dormant forms, indicating broad effectiveness.