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April 30, 2026Annals of Medicine0 citationsOpen Access

Performance of MALDI-TOF-MS in M-Protein Detection in Plasma Cell Disorders

Performance and additional benefits of MALDI-TOF-MS in M-protein detection in plasma cell disorders

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Authors

MDMengmeng DongHYHongying YeXXXiao Xiao

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Overview

Randomized trial evaluates MALDI-TOF-MS effectiveness in detecting M-proteins in plasma cell disorders, highlighting significant advantages.

Key Points

  • To evaluate the performance and supplementary benefits of MALDI-TOF-MS for detecting M-proteins in plasma cell disorders.
  • M-protein detection in blood samples of 137 patients with plasma cell disorders using MALDI-TOF-MS.
  • Comparison with gold standards including SPEP, IFE, and sFLC to assess performance.
  • Confirmation of discrepant results by urine IFE.
  • MALDI-TOF-MS showed a detection rate of 98.5% compared to other standard methods (SPEP 75.9%, IFE 86.9%, sFLC 71.5%, urine IFE 76.0%).
  • Sensitivity for κ and λ light chains was 75.8% and 80.0%, respectively, while IgG and IgA sensitivities were 93.5% and 65.5%.
  • Identification of LC glycosylation in 17 patients and correlations with treatment response observed.

Cite This Study

Dong et al. (2026) studied this question.

synapsesocial.com/papers/69f2f1dc1e5f7920c63877a2https://doi.org/10.1080/07853890.2026.2654933
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