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May 1, 2026SHILAP Revista de lepidopterologíaOpen Access

Enhanced secretion of extracellular proteins in Trichoderma reesei through targeted deletion of a kinesin encoding gene

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Authors

HCHuizhen ChenYZYuqiang ZhengHSHaowen Sun

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Overview

Randomized trial shows improved cellulase production in Trichoderma reesei through targeted gene deletion, suggesting a novel genetic strategy.

Key Points

  • The aim is to evaluate how deleting the kinesin gene kin1 affects protein secretion and cellulase production in Trichoderma reesei.
  • Targeted deletion of kinesin gene kin1 in Trichoderma reesei.
  • Assessment of morphological changes, biomass increase, and cellulase activity.
  • Transcriptome analysis to evaluate gene expression levels.
  • The Δkin1 strain exhibited increased cellulase production, with higher titers and activities during fermentation.
  • Alterations in hyphal morphology included shorter, branched hyphae and improved biomass.
  • Gene expression of major cellulase genes remained largely unchanged despite enhanced enzyme production.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/69f44223967e944ac5565dbahttps://doi.org/10.1080/21501203.2026.2659416
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