PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
May 1, 2026

Gonadotrope Remodeling in Sustained Low Estrogen States: Single-Cell Transcriptomic Analysis Reveals Gonadotrope Subtypes and Activation of Stem Cell Populations.

View Full Paper
Ask AI
Bookmark
Share

Authors

AOAngela K. OdleTMTiffany K. MilesAHAshley Herdman

Discussion

Loading...

Member takes

Overview

Randomized trial investigates the effects of low estrogen on pituitary function, suggesting insights into menopausal physiology.

Key Points

  • This research aims to explore how low estrogen levels impact gonadotrope function and stem cell activation in the pituitary gland.
  • Used a VCD-induced ovarian failure model to decrease estrogen levels gradually.
  • Conducted single-cell RNA sequencing to analyze gene expression in gonadotropes.
  • Identified two distinct gonadotrope populations based on gene expression signatures.
  • GON1 population significantly increased in low estrogen conditions, expressing stem cell activation markers.
  • Gonadotropins FSH and LH levels rose 8-15-fold, correlating with increased Fshb and Lhb mRNA levels.
  • Sox2-positive stem cells showed enhanced expression of transitional progenitors, indicating stem cell activity.

Cite This Study

Odle et al. (2026) studied this question.

synapsesocial.com/papers/69f442d4967e944ac55663a2https://doi.org/10.1093/biolre/ioag091
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 18686 scRNA-seq of pituitary from letrozole-induced PCOS mouse model reveals abnormal prolactin secretion2024
  2. 2Transcriptomic signatures of mouse ovarian aging and estropausal transition at single cell resolution2024 · 4 citations
  3. 3Single-cell atlas of the mouse ovary reveals molecular drivers of aging and senescence during the estropausal transition2026
  4. 4Estradiol treatment induces both shared and unique gene regulation and networks in adipose cell types of gonadectomized obese XX and XY mice2026
  5. 5A Dose-Response Study on Functional and Transcriptomic Effects of FSH on Ex Vivo Mouse Folliculogenesis2024 · 13 citations