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May 1, 2026

Pvf/Pvr signaling relieves white spot syndrome virus-induced lipid consumption to inhibit viral infection in shrimp.

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Authors

ZCZi-Hua ChengPLPing-Ping LiuZFZe-Xuan Fan

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Overview

Randomized trial shows Pvf/Pvr signaling reduces lipid depletion from WSSV infection in shrimp, suggesting potential for aquaculture management.

Key Points

  • This research aims to clarify the role of Pvf/Pvr signaling in shrimp's antiviral response and lipid metabolism under WSSV infection.
  • Examined the effects of MjPvf2/MjPvr3 signaling on lipid metabolism during WSSV infection.
  • Utilized pharmacological inhibition of lipid synthesis to assess antiviral effects.
  • Analyzed lipid levels and viral replication rates post-intervention.
  • MjHSD promoted lipid synthesis and restored lipid levels, decreasing WSSV replication.
  • Pharmacological inhibition of lipid synthesis negated the antiviral effects of Pvf/Pvr signaling.
  • Significant insights were provided regarding lipid metabolism's influence on antiviral immunity.

Cite This Study

Cheng et al. (2026) studied this question.

synapsesocial.com/papers/69f443e8967e944ac5567101https://doi.org/10.1128/jvi.00182-26
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