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May 2, 2026Journal of Biological Chemistry0 citationsOpen Access

Potassium suppresses allosteric activation of ZAP-70-dependent T Cell Receptor signaling

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SRSwarnendu RoySSSoumee SenGuptaKGKaustav Gangopadhyay

Key Points

  • This research investigates how potassium influences the activation of ZAP-70 in T cell receptor signaling.
  • Analyzed T cell receptor signaling dynamics using potassium variations.
  • Examined ligand discrimination in T cells exposed to varying potassium levels.
  • Potassium significantly inhibited allosteric activation of ZAP-70-dependent signaling pathways.
  • Demonstrated that increased potassium levels lead to reduced T cell response amplitude.

Abstract

dynamics are integral to T cell ligand discrimination and fundamental to turning off the signaling during T cell quiescence.

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Cite This Study

Roy et al. (2026) studied this question.

synapsesocial.com/papers/69f5939871405d493affeab1https://doi.org/10.1016/j.jbc.2026.113083
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