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May 2, 20260 citations

Conserved deletion of two consecutive glycine residues in the 100K protein is a critical determinant of FAdV-11 pathogenicity.

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BWBaiyu WangLQLuyao QiuYZYutao Zhu

Key Points

  • To investigate how two consecutive glycine residues in the 100K protein influence the pathogenicity of FAdV-11.
  • Comparison of mortality rates between mutant and wild-type FAdV-11 in SPF chickens.
  • Assessment of viral load and pathology associated with both strains.
  • 10% mortality observed in SPF chickens infected with the mutant versus 100% for the wild-type.
  • Mutant showed reduced viral load and less severe pathology compared to wild-type.

Abstract

, the mutant caused only 10% mortality in SPF chickens versus 100% for the wild-type, with attenuated pathology and viral load. These results identify the two glycine residues as critical virulence determinants of FAdV-11, essential for both viral assembly and late gene regulation, thereby providing potential targets for developing attenuated vaccines.

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69f5941871405d493affeef3https://doi.org/10.1080/21505594.2026.2664958
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