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May 2, 2026

Cardiac fibroblast-derived CCN1 aggravates diabetic cardiomyopathy through ITGAV-ITGB1/integrin αvβ1-mediated autophagy inhibition.

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Authors

BHBo‐ang HuLZLei ZhangMSMing Song

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Overview

Randomized trial reveals CCN1's role in impairing heart function in diabetes, suggesting new treatment pathways.

Key Points

  • This research investigates how fibroblast-derived CCN1 aggravates diabetic cardiomyopathy by inhibiting autophagy.
  • Identified ITGAV-ITGB1/integrin αvβ1 as the receptor for CCN1 in cardiomyocytes.
  • Conducted molecular dynamics simulations and co-immunoprecipitation experiments to study CCN1 interactions.
  • Analyzed signaling pathways involved, specifically PTK2/FAK-MTOR, affecting cardiomyocyte autophagy.
  • CCN1 significantly inhibits cardiomyocyte autophagy, contributing to cardiac dysfunction in diabetic conditions.
  • ITGAV-ITGB1/integrin αvβ1 interaction was confirmed, activating the downstream PTK2/FAK-MTOR signaling pathway.
  • Deletion of CCN1 ameliorated cardiac dysfunction and restored autophagic activity.

Cite This Study

Hu et al. (2026) studied this question.

synapsesocial.com/papers/69f5945c71405d493afff1cbhttps://doi.org/10.1080/15548627.2026.2667721
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac fibroblast-derived CCN1 aggravates diabetic cardiomyopathy through ITGAV-ITGB1/integrin αvβ1-mediated autophagy inhibition2026
  2. 2Extracellular matrix protein CCN1 regulates cardiomyocyte apoptosis in mice with stress-induced cardiac injury2013 · 23 citations
  3. 3Cell death‐inducing DFFA‐like effector C/CIDEC gene silencing alleviates diabetic cardiomyopathy via upregulating AMPKa phosphorylation2021 · 11 citations
  4. 4Tenascin-C drives cardiovascular dysfunction in a mouse model of diabetic cardiomyopathy2025
  5. 5Hyperactivation of ATF4/TGF-β1 signaling contributes to the progressive cardiac fibrosis in Arrhythmogenic cardiomyopathy caused by DSG2 Variant2024 · 15 citations