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May 2, 20260 citations

Discovery of Potent and Selective Benzothiophene Difluoromethyl Phosphonate (DFMP) PTPN2/N1-Dual Inhibitors.

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XZXiao Mei ZhengDCDavid A. CanditoJJJames Jewell

Key Points

  • The study aims to identify and characterize dual inhibitors of PTPN1 and PTPN2, focusing on DFMPs.
  • Investigated the structure-activity relationship of DFMPs as inhibitors.
  • Evaluated the role of SLC19A1 in the transport of these compounds.
  • Identified potent and selective dual inhibitors for PTPN1 and PTPN2.
  • Emphasized the critical role of SLC19A1 in transporting DFMP molecules.

Abstract

as promising structurally differentiated tool to study PTPN1/N2 inhibition and underscore the importance of SLC19A1 in the transport of DFMPs.

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Cite This Study

Zheng et al. (2026) studied this question.

synapsesocial.com/papers/69f5947e71405d493afff3bahttps://doi.org/10.1021/acs.jmedchem.5c03738
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