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May 2, 2026

GO-Y078 Triggers Program Cell Death in Human Cervical Cancer Cells Via MAPK Activation-Dependent Apoptotic Caspases Signaling.

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Authors

CLChung‐Yuan LeePWPo-Hui WangYHYi‐Hsien Hsieh

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Overview

Randomized trial demonstrates GO-Y078 triggers cell death in cervical cancer cells, indicating therapeutic potential.

Key Points

  • This research aims to explore the apoptotic effects of GO-Y078 in human cervical cancer cells and its underlying mechanisms.
  • GO-Y078 was tested on SiHa and HeLa cervical cancer cells to assess anti-cancer effects.
  • Cell viability, chromatin condensation, and activity of caspases were measured post-treatment.
  • Co-treatment with ERK and p38 inhibitors was performed to evaluate the role of the MAPK pathway.
  • GO-Y078 significantly reduced cell viability and induced chromatin condensation in cervical cancer cells.
  • Active caspase-3, -8, and -9 were increased, indicating apoptosis following GO-Y078 treatment.
  • Inhibition of the MAPK pathway decreased caspase activation, highlighting the pathway's role in GO-Y078-induced apoptosis.

Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/69f5947e71405d493afff402https://doi.org/10.1177/15347354251411859
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