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Synapse
May 2, 20260 citations

From FIRST-CARE to RUSTIC Practice: How ROBUST Is the Evidence for Drug-coated Balloon Dilation in Urethral Strictures? A 2026 Clinical Trial Update.

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NRNavid RoesslerJKJakob KlemmMVMalte W. Vetterlein

Key Points

  • The aim is to evaluate the efficacy of drug-coated balloon dilation for treating urethral strictures.
  • Utilized the drug-coated balloon Optilume® for dilation
  • Assessed outcomes in recurrent anterior urethral strictures
  • Highlighted ongoing trials such as BALDIKA, FIRST-CARE, and RUSTIC
  • Demonstrated durable functional improvement in treated patients
  • Showed high freedom from repeat intervention
  • Evidence continues to evolve through ongoing clinical trials

Abstract

Drug-coated balloon dilation with Optilume® demonstrates durable functional improvement and high freedom from repeat intervention in recurrent anterior urethral strictures. Ongoing trials, including BALDIKA, FIRST-CARE, and RUSTIC, will further define its role across diverse patient populations.

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Cite This Study

Roessler et al. (2026) studied this question.

synapsesocial.com/papers/69f5947e71405d493afff49ahttps://doi.org/10.1016/j.euf.2026.04.009
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