Population
Myosin molecules (preclinical model)
Design
Preclinical
Key result
Mavacamten promotes diastolic relaxation and reduces systolic contractile output by stabilizing the myosin interacting-heads motif and stalling motor force generation.
Authors
Loading...
May warrant systolic monitoring with mavacamten; leaves open translational relevance of IHM mechanism from animal models.
Mavacamten inhibits myosin activity by stabilizing the interacting-heads motif, explaining its molecular mechanism for promoting diastolic relaxation while reducing systolic contractile output.
McMillan et al. (2026) studied this question. Mavacamten promotes diastolic relaxation and reduces systolic contractile output by stabilizing the myosin interacting-heads motif and stalling motor force generation.