Copper-Based Metal Organic Frameworks for Controlled Curcumin Delivery and Antimicrobial Activity.

Key Points

• The aim is to evaluate the antimicrobial activity and drug delivery potential of copper-based metal organic frameworks loaded with curcumin.
• Developed and tested copper-based metal organic frameworks (MOFs) for curcumin loading and delivery.
• Measured inhibition rates and cell viability in human dermal fibroblasts.
• Compared the performance of curcumin-loaded HKUST-1 to pristine HKUST-1.
• Inhibition rates of microbial growth above 99% with curcumin-loaded HKUST-1.
• Significantly improved cell viability in human dermal fibroblasts compared to pristine HKUST-1.
• Demonstrated that curcumin-loaded HKUST-1 is stable, biocompatible, and pH-responsive.

Abstract