Penicipenoids A-G, antioxidant and anti-inflammatory cadinane sesquiterpenoids with rearranged carbon skeletons from the marine sponge symbiotic Penicillium sp. 5975.

Key Points

• This research aims to identify and evaluate the antioxidant and anti-inflammatory properties of penicipenoids A-G derived from marine sponge-derived symbiotic Penicillium sp.
• Isolated penicipenoids A-G from marine sponge symbiotic Penicillium sp. 5975.
• Evaluated their effects on oxidative stress and inflammation using transgenic fluorescent zebrafish embryos.
• Penicipenoids A-G significantly reduces oxidative stress markers in transgenic zebrafish embryos.
• Demonstrated anti-inflammatory activity with a reduction in inflammatory cytokines compared to controls.