The global increase in neurodegenerative disorders such as Alzheimer’s disease has prompted the search for effective non-pharmacological interventions. Chrono-exercise which is the physical training aligned with circadian rhythms has emerged as a novel strategy to strengthen cognitive resilience. This study explores the impact of chrono-exercises, incorporating aerobic, resistance, and combined modalities, performed at the early dark (ZT13) and early light (ZT1) phases in an aluminum chloride (AlCl 3 )-induced rat model of neurodegeneration. One hundred male Wistar rats aged 2–3 months will undergo structured exercise interventions following AlCl 3 exposure. Neurobehavioural assessments including novel object recognition and open-field tests along with grip strength analysis, biochemical profiling and histological evaluations of brain and muscle tissues will be conducted. We hypothesize that the timing of combined aerobic-resistance exercise critically influences neuroplasticity and cognitive performance. Findings are expected to guide circadian-based exercise prescriptions to counter cognitive decline and enhance brain health in aging populations.
Fairof et al. (2026) studied this question.