This review aims to consolidate the behavioral paradigms applied in rat models of aluminum chloride-induced Alzheimer’s disease, focusing on key methodological differences.
Conducted a structured narrative review incorporating systematic elements following PRISMA guidelines
Reviewed literature from PubMed, Web of Science, and Scopus
Emphasized dose, exposure duration, route of administration, and behavioral assessments such as the Morris water maze and Y-maze
Predominance of oral administration and low-to-moderate aluminum chloride doses observed
Most studies used subchronic exposure durations lasting 31–60 days
Aluminum chloride exposure linked to multidomain behavioral impairment and significant hippocampal and cortical histopathology