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May 6, 2026FEBS Journal0 citations

ICAM-1 inhibition of inflammation via ERK/STAT3 enhances cognition in Alzheimer's model

ICAM ‐1 mediated inhibition of microglial inflammation through ERK / STAT3 signalling pathway improves cognitive functions in 5xFAD mouse model of Alzheimer's disease

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Authors

SGSoumita GoswamiNGNimai GoraiSBSubhas C. Biswas

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Overview

Research demonstrates cognitive function improvements in Alzheimer's disease model by inhibiting neuroinflammation and enhancing amyloid-β clearance.

Key Points

  • This research aims to explore the role of ICAM-1 in modulating microglial functions in Alzheimer's disease.
  • Investigated microglial activation in response to ICAM-1 in a 5xFAD mouse model.
  • Analyzed the effects of ICAM-1 on Aβ-associated microglial inflammation and phagocytosis.
  • Monitored cognitive improvements through behavioral assessments in the AD mouse model.
  • ICAM-1 reduced amyloid-β plaque load in the hippocampus.
  • Enhanced phagocytic ability of microglia was observed with ICAM-1 treatment.
  • Cognitive functions showed significant improvement in the 5xFAD mouse model.

Cite This Study

Goswami et al. (2026) studied this question.

synapsesocial.com/papers/69fa8e0b04f884e66b5304ebhttps://doi.org/10.1111/febs.70531
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